Biotechnology, gene and medicine

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A gene and its function

A gene is the most fundamental biological unit of heredity. It is a portion of deoxyribonucleic acid (DNA) that contributes to a function and can be distinguished by homology or sequence. A gene may also be known as a base sequence. Adenine (A), thymine (T), cytosine (C), and guanine (G) are the bases involved (MedicineNet.com 11). The combination of these bases defines a gene's function. A human typically has thousands of chromosomes, each of which is made up of billions of base pairs. These genes are responsible for a person's unique characteristics. Gene research began in 1869, when the chemical element DNA was found in cells. However, during this time, the real function of the DNA was unknown. The term "gene" was first used in 1909. Many discoveries were made during the later years, with notable improvements such as in 1956 when DNA was created artificially. The first single gene was isolated in 1969 (MedicineNet.com 13). In the following year, the first artificial gene was made. Currently, genes are used in numerous medicine areas including research, making medicine, clinical practice, genetic counseling, clinical diagnostic and laboratory activities.

Use of Genes in Medicine

Notably, with new developments, research and laboratory projects, myriad applications of genes in medicine have been realized. Drug manufacturing plants form part of the gene uses. Plants are applied in medicine in diverse areas such as making vaccines. Specialists genetically engineer plants to produce human antibodies and hormones. Bananas are an example of plants genetically engineered to make human vaccines (About Genetics 13). Scientists require transgenic plant during this process. Transgenic plants are prepared by mixing foreign DNA with protoplasts. A small electric current is passed through the mixture of foreign DNA and protoplasts to make tiny holes in the cell and allow foreign DNA to enter. The protoplast is left to grow into a plant. Once the plant is fully developed, medicine is extracted from its seeds.

Moreover, genes are used in bacteria to make medicine. The bacteria are first specially modified by scientists and referred to as transgenic bacteria. An example of this technology include making of insulin. In the past, if one had diabetes, doctors prescribed insulin to the patient, which would have been gotten from a pig. Another alternative was extracting it from human cadavers, which is not only costly but also disturbing for many people (About Genetics 14). Furthermore, with the genes technology, bacteria are now used to make medicines and vaccines. This is made possible by the single-celled characterization of foreign genes. Notably, when injected with foreign genes, the bacteria live and produce like normal organisms. The product contains human proteins, used for vaccines and medicines.

Genes are used in farm animals to produce drugs and vaccines. "Gene pharming" is the term applied to describe the process as mentioned earlier. The first step entails creating transgenic farm animals. During this process, scientists use a needle thinner than a human hair to inject foreign DNA sequence (About Genetics 16). An example include making of antithrombin III. Its function entails preventing blood clotting when a person is undergoing surgery. A DNA sequence for antithrombin III is injected into goat eggs. The transgenic eggs are then transplanted into female goats. Antithrombin III is then extracted from the milk of these transgenic goats. Scientists are also planning to use the genetic technologies in making "magic bullets" drugs (About Genetics 19). These drugs are to be designed such that they would target specific antigens but leave healthy tissues untouched. Germline gene therapy is a well-known application of gene in medicine. The therapy involves transferring DNA to cells, which produce reproductive cells including sperms and eggs. This therapy enables disease-causing gene variants to be corrected. Therefore, the disease-causing gene variants are prevented from passing down from one generation to another (YourGenome 27).

The Use of Genetic Alteration for Health Benefits

The use of this genetic alteration enables the correction of disease-causing mutations thus enabling generations to lead a healthy life. The future generations are also spared from suffering the corrected disease (YourGenome 31). Another additional advantage of this gene alteration is the reduction of health care costs. This is achieved when the genetic condition is completely removed, thus preventing future costs that would have been incurred in treating the disease. Germline gene therapy also has the capacity to eliminating certain genetic conditions from the population. Example of a disease that can be eliminated is Huntington's disease, in the same way, which maladies like polio have been eradicated by global vaccination programmes.

Somatic Gene Therapy

Another use of genes in medicine is application of somatic gene therapy. The therapy is slightly familiar with germline gene therapy. However, the two therapies use different types of cells. In somatic gene therapy, somatic cells, which make up most of the body, are used. Example of somatic cells include cells of the bone marrow. About Genetics (21) assert that in this therapy, the new DNA does not enter reproductive cells unlike in the germline gene therapy. The technique involves transferring appropriate and normal alleles to the patient. This therapy permanently corrects the recipient's disorder. The cells are inserted into the bone marrow cells of the patient, which continuously divides during an individual's life to produce blood cells. This therapy is employed to correct many disorders such as in utero to avert a disease that may impair a baby's health.

Genetic Testing and Predicting Disorders

Genes in medicine are applied in confirming a diagnosis and predicting a possible disorder. It is possible to confirm a previous diagnosis or make a fresh one when using laboratory genetic tests. Additionally, disorders likely to occur in future can be predicted in advance. For instance, a disorder in an unborn child can be predicted and prevented from developing into a deadly disorder that may not only affect the baby but also the mother. In addition to predicting disorders, it also enables healthcare professionals to use a person's genotype information to prescribe closely tailored drugs.

Ethical Implications

Use of genes in medicine is still in its developing stages. Many ethical implications are facing the practice, as new others continue arising. One of the primary ethical implication is ownership and control of genetic information. It remains a dilemma on who should own or control genetic information, For instance, if inherited genetic characteristics or gene products are derived from an individual or a specific community, it is not clear regarding the ownership and control of that genetic information. Potential owners and controllers include the individual, the society involved, the research sponsor, the laboratory used, the national government, the global society and research institutes. The ensuing conflict would transpire and divide the involved party thereby leading to possible conflicts.

Reproductive and Privacy Issues

Reproductive issues is another ethical implication associated with the use of genes in medicine. Using genetic information in reproductive cells creates the possibility of those genetically altered reproductive cells being passed on to future generations. Germline gene therapy is an example of this practice. It encompasses genetically manipulating reproductive cells to correct disease-causing gene variants and prevent them from moving down to the next generations. The ethical implications arise since it is possible for judgment or technology errors occurring. These may have far-reaching consequences once passed on from one generations to another. Additionally, these errors may lead to damage of healthy cells, causing diseases such as cancer. The virus used in the genetic alteration may also recover their original ability once introduced in the body thus causing illnesses or diseases. Other issues associated with productive matters include human cloning, preimplantation genetic diagnosis, and designer babies.

The Genetic Divide and Social Institutions

The genetic divide is also an ethical implication of using genes in medicine. Most developed countries are extensively involved in medical genetics and research. However, the developing countries are in many ways behind since such nations lack sufficient or required medical applications of biotechnology. The widespread use of medical genetics has the potential to create a genetic divide between the developed and developing counties. This may be intensified if the developed countries are not willing to share their biotechnology developments and genetic products with the developing countries. The deprivation may arise when the developed countries feel that it is not right to share genetic information accrued from their own people.

Medical Genetics and Ethical Concerns

Medical genetics has effects on social institutions, which is another ethical implication. Genetic laboratory tests disclose information concerning the individual or the group of people involved. Information from one individual can also be used to reveal more details about his or her family. This may lead to privacy issues especially if other people in research access the genetic information or if the report is published in a research paper or journal. According to About Genetics (22), when a person's genetic information is made public, the individual and his or her family might fall susceptible to discrimination. The discrimination is likely to happen in insurance and employment. Other people who might have malicious intentions may also misuse the genetic information.

Conceptual Issues and Global Perspective

Numerous conceptual and philosophical issues that bring about ethical implication surround use of genetics in medicines. One such point is the concept of human behavior. It is considered that genes influence a person's behavior. This implies that through genetic alterations, a person’s behavior is changed. This further implies that genetic alterations control human behavior, which should be a natural and not a designed trait. Another issue under this ethical concern is how to draw a line between enhancement and medical treatment. Yourgenome (33) explains that whereas genetic alterations should only be undertaken for medical related issues, others bypass this line and utilize it for personal enhancement. The main problem lies in determining where a line should be drawn between the two. Another issue under this ethical implication concerns human responsibility. There is no definite rule defining where a person's responsibility lies regarding genetic makeups.

Global Perspective and Examples

Medical genetics and its applications in medicine have been gaining considerable presence in the past three decades. The extent of genetic testing has increased as well as its application. The global perspective of the use of genes in medicine is wide and varying. However, there are numerous perspectives similar to the international population. One of the general global perspectives entails increasing awareness and discussion regarding the risks and benefits associated with medical genetics. Healthcare professionals should discuss and create awareness to the public regarding implications of genetic testing and application. Healthcare professionals are key stakeholders involved in medical genetics and current practices, thereby making them most appropriate for addressing patient concerns revolving around use of genes in medicine.

Implications of Disclosing Genetic Information

The impact of disclosing genetic information spur discrimination and reduced privacy. For instance, when a specific genetic information regarding a disease likely to be passed to other generations is discovered, the patient might be discriminated by other people. Additionally, when seeking personal insurance, an individual might be judged with regard to his or her genetic information. For instance, in a study surveying 36 counselors, 28% of them affirmed that an insurer had approached them to request for patient information (Michelle et al. 1023). This has created an implication whereby people feel insecure to undergo genetic tests for fear that the information might be used to their disadvantage. Ethical principles in medical healthcare should also be upheld (Wertz, Dorothy and Fletcher 31). The patients and their families should be given adequate information regarding the tests and how the information will be used.

Importance of Educational Resources

International community feels that more educational resources on genetics should be provided and made accessible to the public (Michelle et al. 1025). The resources should be provided in varying content, depth, and length with regard to the context of the various areas in the genetics topic. Examples of these areas include the extent of application, possible adverse impacts, ethical concerns, costs, insurability of family members, and the benefits. Most people also feel that it is not only the patients who should be provided with educational resources but also healthcare professionals to increase their knowledge and skills on the subject matter. MedicineNet.com (14) claims that with more resources, finance, and technological advancements, better applications of genetic information will be realized and utilized positively to enhance people’s lives. New ways of mitigating the downsides and risks will also likely be discovered and used to help patients.

Conclusion

Gene is an essential component of an individual's biological unit. Many research and laboratory tests have been conducted to get a more comprehensive understanding of genes and how they can be used in medicine. The use of genes in medicine is applied in many areas such as manufacturing drugs using plants, making drugs using animals and gene pharming. Genetic information is also employed in germline gene therapy, somatic gene therapy, and in predicting possible disorders. Use of genes in medicine is still in its developing stage, thus making it susceptible to many ethical implications. These ethical implications include reproductive issues, privacy issues, discrimination, genetic divide, and conceptual implications. More educative resources should be made available to patients, healthcare professionals, and the public to create more awareness of the practice and application of genetic information. With more research being conducted, safer applications of genetic information are expected in the new future. Healthcare professionals should uphold the principles of medical ethics when carrying out their utilization of genetic information.

Work cited

About Genetics. "Making Medicines | Understanding Genetics." Genetics.Thetech.Org, 2017, http://genetics.thetech.org/about-genetics/making-medicines.

Michelle et al. "Genetics and Personal Insurance: The Perspectives of Canadian Cancer Genetic Counselors." Journal of Genetic Counseling, vol 24, no. 6, 2015, pp. 1022-1036. Springer Nature, doi:10.1007/s10897-015-9841-9.

MedicineNet.com. "Medical Definition of Gene." Medicinenet, 2017, https://www.medicinenet.com/script/main/art.asp?articlekey=3560.

Wertz, Dorothy C, and John C Fletcher. Genetics and Ethics in Global Perspective. Dordrecht, Springer Netherlands, 2004.

Yourgenome. "Is Germline Gene Therapy Ethical?." Yourgenome.Org, 2017, https://www.yourgenome.org/debates/is-germline-gene-therapy-ethical.

January 05, 2023
Category:

Science Education

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Genetics Learning

Subject area:

Gene DNA Study

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